Think about how these sort of shows are done on TV... Prerecord as much as possible, especially any sketches with people contributing from multiple locations. Prerecording will allow you to correct sync issues or do retakes until you are happy. Maybe have a live host, but keep all the content prerecorded. You can then transmit it on multiple platforms, Zoom/Youtube/Facebook or whatever You need someone to produce/call the show A tech handling playback Possibly additional techs handling the host's feed/camera/audio If you can't get all these people into one (socially distances) room, then you need GOOD communication between all the parties. I've worked on a few corporate virtual conferences, most use Infinifty comms to communicate. https://www.unityintercom.com/ Basically using your own devices as intercoms just like talkback in a theatre. This can be quite an expensive full featured system, but there is a 7 day free trial.. There are rental and cloud options, which are cheaper but not as fully featured as running your own server.