QUOTE (Bobbsy @ 3 Jul 2009, 1:42 PM)

However, besides the hardware, you'll need software that can do four channel working...
Q Lab is capable of that however.
I have a Mac Mini running Q Lab into a M-Audio ProFire Lightbridge, which gives us 32 outputs on ADAT, or analog outputs when paired with a few Behringer ADA8000s. However, we also have Q Lab attached to a Yamaha digital desk via MIDI, and using MIDI cues from Q Lab we can fade and pan on the desk rather than in QLab - and using routing you can manipulate your sound effects across more outputs than you have on your Mac.
However, for your needs I would look at the M-Audio cards as suggested, or the Edirol range of cards, which also offer comparative quality within the same lower-end price bracket.
Also - remember that Q Lab can address multiple sound cards simultaneously, so you could get away with running two channels through the internal sound card as well as whatever else you attach - although these can't be run from the same cue - (each cue is routed to an output device) - so you'd have to break down the multi-channel sound into different files and fire the cues simultaneously. (Unless you create aggregate sound devices to make all your sound cards appear in software as one device, but then it's just getting complicated.)